Alzheimer's disease (AD) is a neurodegenerative disorder with no conclusive remedy. Yohimbine, found in Rauwolfia vomitoria, may reduce brain inflammation by targeting tumour necrosis factor-alpha (TNFα), implicated in AD pathogenesis. Metoserpate, a synthetic compound, may inhibit TNFα. The study is aimed at assessing the potential utility of repurposing metoserpate for TNFα inhibition to reduce neuronal damage and inflammation in AD. The development of safe and effective treatments for AD is crucial to address the growing burden of the disease, which is projected to double over the next two decades. Our study repurposed an FDA-approved drug as TNFα inhibitor for AD management using structural similarity studies, molecular docking, and molecular dynamics simulations. Yohimbine was used as a reference compound. Molecular docking used SeeSAR, and molecular dynamics simulation used GROMACS. Metoserpate was selected from 10 compounds similar to yohimbine based on pharmacokinetic properties and FDA approval status. Molecular docking and simulation studies showed a stable interaction between metoserpate and TNFα over 100 ns (100000 ps). This suggests a reliable and robust interaction between the protein and ligand, supporting the potential utility of repurposing metoserpate for TNFα inhibition in AD treatment. Our study has identified metoserpate, a previously FDA-approved antihypertensive agent, as a promising candidate for inhibiting TNFα in the management of AD.

Fractional time derivative is considered in the description of the unsteady fluid flow through a horizontal microchannel filled with porous material. The resultant governing equations were solved using the Laplace transform technique and the method of undetermined coefficient in the Laplace domain. The Riemann-sum approximation approach was then utilized to obtain the solution in the time domain. The results were then simulated and presented as line graphs utilizing MATLAB (R2015b) to study the effects of the parameters involved in the fluid flow.

Globally, energy demand and environmental pollution affect the development of society. However, solar fuel generation via photocatalytic water-splitting became the most viable approach to address the global energy crisis. Cadmium sulfide is considered an ideal material for solar fuel (hydrogen) generation due to its promising, low-cost, suitable bandgap energy, desired band alignment, affordability, and simple preparation method. However, the solar-to-hydrogen (STH) conversion efficiency of CdS-based materials still needs to improve due to the high rate of photogenerated electron-hole pair recombination and photocorrosion, resulting in poor photocatalytic performance. Herein, an emerging approach for enhancing the stability and photocatalytic activity of CdS is discussed, including designing heterostructure, co-catalyst loading, etc., with a focus on charge carrier separation and transfer. Particular attention is given to the mechanism of the emerging approach that influences photocatalytic water-splitting. This review focuses on designing and developing of strategy for enhancing anti-photocorrosion CdS-based materials for solar fuel generation. Notably, the solar H2 production improvements achieved in studying the CdS material as the main photocatalyst, not a co-catalyst, were exclusively reviewed and discussed. The prospective, challenges and development in preparation for anti-photo corrosion CdS are discussed. Thus, this review would likely motivate researchers to broaden the applications for CdS-based materials in solar fuel (hydrogen) generation in an economical and eco-friendly approach.

Abstract Background Sustained viral suppression in HIV is essential to minimize drug resistance, reduce secondary transmission and improve health outcomes necessary to achieve the UNAIDS 95-95-95 strategy. There is dearth of information on viral suppression among adults in Nigeria. Identifying correlates of sustained viral suppression will inform treatment guidelines especially for people at risk and provide recommendations to policy makers. Methods We collected sociodemographic and HIV-related data from a cross-section of 730 HIV-positive adults receiving antiretroviral therapy from six secondary health facilities in northern Nigeria, between October 2021 and February 2022. Sustained viral suppression was defined according to the Nigerian National Guideline for HIV Prevention, Treatment and Care as a viral load below the detection threshold of less than 20 copies of HIV RNA/ml. Proportion of participants with sustained viral suppression was estimated and a multivariable analysis used to identify independent correlates of sustained viral suppression. Results The sustained viral suppression rate among HIV-positive adults on ART was 35.7% [95% CI: 32.2, 39.5]. Being married [AOR 2.01; 95% CI: 1.34, 3.03] and having secondary education [AOR 0.43; 95% CI: 0.26, 0.74] were significantly associated with sustained viral suppression. Respondents on treatment for 5-10 years [AOR 1.76; 95% CI: 1.17, 2.64] and those taking two or more pills [AOR 5.67; 95% CI: 3.74, 8.62] were more likely to have sustained viral suppression. Previous treatment for opportunistic infection [AOR 0.24; 95% CI: 0.15, 0.41] significantly decreased the likelihood of sustained viral suppression. Conclusion Sustained viral suppression rates among HIV-positive adults on ART in the six facilities were suboptimal. While being married, taking two or more ART pills and being on treatment for 5-10 years increased the likelihood of having a suppressed viral load, being educated up to secondary level and previous treatment for opportunistic infection decreased the odds of having sustained viral suppression. There is a need to improve viral load monitoring and direct viral suppression interventions towards at risk population. Disclosures All Authors: No reported disclosures

People living with HIV (PLHIV) are at higher risk of poor outcomes of SARS-CoV-2 infection. Here we report the pooled prevalence of COVID-19 vaccine acceptance/uptake and determinants among this vulnerable population of PLHIV based on a systematic review and meta-analysis of studies published by 25 August 2023. Among the 54 included studies (N = 167,485 participants), 53 (N = 166,455) provided data on vaccine acceptance rate, while 27 (N = 150,926) provided uptake data. The global prevalences of COVID-19 vaccine acceptance and uptake were 67.0% and 56.6%, respectively. Acceptance and uptake rates were 86.6% and 90.1% for the European Region, 74.9% and 71.6% for the Region of the Americas, 62.3% and 78.9% for the South-East Asian Region, 64.6% and 19.3% for the Eastern Mediterranean Region, 58.0% and 35.5% for the African Region, and 57.4% and 44.0% for the Western Pacific Region. The acceptance rate increased from 65.9% in 2020 to 71.0% in 2022, and the uptake rate increased from 55.9% in 2021 to 58.1% in 2022. Men, PLHIV aged ≥40 years and those who had recently received the influenza vaccine were more likely to accept and receive the COVID-19 vaccine. Factors associated with lower uptake included Black race, other races (Latinx/Hispanic/mixed race), low education level and being unemployed. Vaccine-related factors associated with higher acceptance included belief in vaccine effectiveness, vaccine trust, perceived high susceptibility to SARS-CoV-2 infection and fear of potential COVID-19 effect in PLHIV. Sustained efforts and targeted interventions are needed to reduce regional disparities in COVID-19 vaccine uptake among PLHIV.

Economic activity and population growth Bauchi metropolis contributed to the emergence of the Tambari Estate to house the state's civil service's senior and junior staff. This has not only increased the need for land to accommodate the various land uses, but it has also posed challenges to proper and efficient layout management. Appropriate land administration is critical to any nation's socioeconomic development and long-term land information systems. In this period, information and new strategies for sustainable land administration are becoming increasingly important. However, the storage and management of land information have continued to remain analog, resulting in difficulties in land boundary litigation and economic losses. In this paper, a digital housing information management system for the Tambari estate in Bauchi Metropolis was developed. ArcGIS 10.7 was used to digitize and update the layout of the estate sourced from the Bauchi State Ministry of Housing while the attribute data like ownership information, plot details, plot type, number of rooms, status, land use, and other relevant information were gotten through fieldwork. The information of each house was entered into an attribute table to create a relational database. The relational database was used to develop the user interface created using Microsoft Visual Basic 6.0 software which then allowed for the development of the housing management system with an interactive interface with username and password. The development of a Housing Information Management System will provide accurate information to the government and stakeholders in a timely and efficient manner for proper planning and decision-making, as well as effective land-use management. The study recommended the implementation of housing information systems by all levels of government. The system will stimulate economic activity, social cohesion, and long-term development.

Truncated distributions arise naturally in many practical situations. It’s a conditional distribution that develops when the parent distribution's domain is constrained to a smaller area. The distribution of a right truncated is one of the types of a single truncated that is restricted within a specific field and usually occurs when the specified period for the study is complete.  Hence, this paper introduces Right Truncated Inverse Generalized Rayleigh Distribution (RTIGRD) with two parameters  is introduced. Then, provided some properties such as; (probability density function, cumulative distribution function (CDF), survival function, hazard function, ‎rth moment, mean,   variance, Moment Generating Function, Skewness, kurtosis, Median, and Mode  for Right Truncated Inverse Generalized Rayleigh Distribution on [0,1].  

The world's energy crisis and environmental problems could be addressed via solar fuel (hydrogen) generation. Thus, the development of non-toxic, inexpensive and high-efficiency photocatalysts is crucial. Spinel ferrite with general formula MFe2O4 (where M=Mg2+, Co2+, Ni2+, Zn2+, e.t.c.) has gained enormous interest in the field of solar energy conversion and storage especially solar fuel (hydrogen) generation via photocatalytic water-splitting. Spinel ferrites are considered as ideal materials for solar fuel (hydrogen) generation due to its promising magnetic recovery, suitable band gap energy, low toxicity, strong thermal stability, affordability, simple preparation method, and magnetic retrieval ability. However, the solar-to-hydrogen (STH) conversion efficiency of spinel ferrite materials is still low due to high rate of photogenerated electron-hole pair recombination, resulting in poor photocatalytic performance. Herein, preparation approach for spinel ferrites is reviewed in details. Importantly, the solar H2 production improvements achieved in the study of the spinel ferrites material as main photocatalyst not a co-catalyst were exclusively reviewed and discussed. Thus, this review would likely motivate researchers to broaden the applications for spinel ferrites-based materials in solar fuel (hydrogen) generation in an economical and eco-friendly approach.

In the present-time, getting admission to study a preferred course of choice in the Nigerian tertiary institutions by prospective applicants is highly competitive. As a criteria, applicants are required to meet the UTME (Unified Tertiary Matriculation Examination (UTME) and five (5) relevant ordinary level credits, including English and Mathematics as a prerequisite before securing admission. However, being wrongly placed for a course that is different from ones choice could negatively affect learning and outcomes. Therefore, proper placement would have tendency of enhancing not only learning and outcomes but also self-esteem; thus improved productivity. This paper has examined students’ performance based on the course sought at entry and course placed to study. The CGPA of 300-Level students in the 2020/2021 session of the Department of Mathematics and Statistics, Yobe State University was used as a particular case for the investigation. Descriptive and Non-parametric techniques were employed. We found that applicants who sought to study computer science or physics at entry but were placed to study mathematics/statistics performed better than those who sought to study chemistry or biology. However, applicants who sought to study chemistry and placed to study mathematics/statistics are fairly better as compared to biology. Conclusively, the results of this study will inform decision makers and tertiary institution managers towards selecting those suitable to study mathematics/statistics if their preferred courses not secured.